HCPCS

# Dupixent HCPCS Code: Your Complete Guide to Billing & Reimbursement

- March 6, 2025
- Posted by Kristen Edwards

06 Mar

Standardized coding systems enable healthcare professionals, insurance providers, and their patients to optimize healthcare operations at every stage, from medical treatment to billing functions. The Healthcare Common Procedure Coding System (HCPCS) functions as a critical system because it establishes unique codes for medical procedures together with services and supplies. Dupilumab, under the brand name Dupixent, serves as an innovative therapeutic agent capable of treating asthma and atopic dermatitis along with chronic rhino sinusitis with nasal polyposis.

Knowledge about the Dupixent HCPCS code becomes essential for healthcare providers, in addition to insurance specialists and members of billing departments, to achieve effective claim processes medical treatment control and healthcare system coordination. The following article examines Dupixent’s HCPCS code with an explanation of its practical usage throughout treatment.

## What is Dupixent?

The treatment medication Dupixent, consisting of dupilumab, serves as an approach for managing moderate-to-severe atopic dermatitis as well as severe asthma, which presents type 2 inflammatory pathways. The medication requires injection through syringes and pens for delivery. Healthcare providers need to utilize particular HCPCS codes to achieve accurate reimbursement for Dupixent billing. The pharmaceutical companies Regeneron Pharmaceuticals, along with Sanofi, developed Dupixent as a biologic drug. Through its mechanism, Dupixent blocks two crucial proteins, IL-4 and IL-13, which regulate inflammatory responses in the human body. Dupixent functions to manage inflammation when it blocks these proteins for moderate to severe atopic dermatitis (eczema), asthma, and chronic rhinosinusitis with nasal polyposis.

Patients benefit substantially from Dupixent because it requires subcutaneous injection administration for treatment of their chronic health conditions. The correct coding of Dupixent needs to be precise because it guarantees both coverage reimbursement and patient treatment management.

## Clinical Indications for Dupixent

The medical authorities approved Dupixent treatment for multiple clinical uses.

- Atopic Dermatitis: Medical professionals utilize Dupixent to treat adults and adolescents aged 12 and above with atopic dermatitis and children within the 6-month to 11-year age group who need systemic therapy.
- Asthma: Dupixent functions as an add-on treatment for severe asthma patients with type 2 inflammation when used together with high-dose inhaled corticosteroids and another maintenance therapy and it is approved for people aged 12 and older and adolescents.

## HCPCS Code for Dupixent

The HCPCS system operates on two fundamental levels, which constitute its structure.

The Current Procedural Terminology (CPT) codes serve the identical role in Level I service codes while Level II provides coverage for non-physician work and medical supplies and equipment. The HCPCS Level II codes encompass Dupixent as part of their medication and treatment administration for outpatient and hospital facilities.

The HCPCS code is j9228. Dupilumab (commercial name Dupixent) treatment receives its coding through the specific HCPCS code J9228 when administered by subcutaneous injection. The billing system recognizes this code to verify Dupixent administration during medical care. The code supports claim processing accuracy because it enables healthcare providers to obtain proper insurance reimbursements.

## How to Use HCPCS Code J9228

Healthcare professionals mainly employ the HCPCS code J9228 to process claims for Dupixent injections they administer. The implementation of code J9228 occurs according to this process:

Documentation: Medical providers must verify that Dupixent treatment is present in patient plans before billing, which requires documentation of all details, including usage information and administration parameters.

Subcutaneous Injection: Healthcare professionals need to state that Dupixent administration occurs through subcutaneous injections because this information determines proper claim submission.

Quantity: A specific number of doses included in the code is determined from the provided dosage amount. The dosage requirements for Dupixent treatment should be included in the insurance claims when specifying vial quantities.

Patient History and Diagnosis: The provider needs to enter appropriate ICD-10 diagnosis codes that reflect which patient conditions Dupixent was prescribed to treat, including asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyposis.

Insurance Claims: The healthcare provider submits J9228 to insurance providers and pertinent information after Dupixent treatment administration. The health insurance company uses this code for both financial processing and eligibility assessment of reimbursement requests.

## Dupixent HCPCS Code and Reimbursement

The HCPCS system stands vital for healthcare practitioners because it functions as the foundation for reimbursement procedures. The healthcare provider gets reimbursement for provided medications and treatments through the proper use of the correct HCPCS code. The medical team seeking reimbursement for Dupixent (dupilumab) treatment needs to adhere to multiple requirements.

Insurance Policies: Each insurance provider maintains independent criteria regarding coverage payments for Dupixent biologic drug prescriptions. Healthcare providers need to check whether Dupixent receives coverage from their patients’ plans together with any necessary pre-authorization protocols.

Dosage and Frequency: Reimbursement processes for Dupixent depend on the treatment requirements of each patient alongside the specific medication dosage amounts. Accurate coding procedures enable proper calculation for the charges they should receive.

National Drug Codes (NDC): The HCPCS code requires insurance carriers to also use National Drug Code (NDC) information for reimbursement of Dupixent. This product identifier and specific dosage information contained in the code helps insurance providers correctly process medical claims and give out reimbursements.

Prior Authorization: Some insurance plans need prior authorization for the administration of Dupixent biologic medications. Additional information together with documentation might need approval from insurance providers.

## Common Billing Issues with Dupixent HCPCS Code

The J9228 procedural HCPCS code generally presents itself as an easy billing process, but several issues can occur during Dupixent injection procedures among healthcare providers.

Coding Errors: A failure to apply the correct dosage, together with improper ICD-10 coding in billing, can extend reimbursement delays. Healthcare providers must follow precision with documentation and maintain double-checks for coding accuracy.

Denials for Unapproved Indications: Dupixent claims to insurance companies will be rejected when the treatment goes beyond an FDA-approved indication. No reimbursement will occur when healthcare providers fail to document their use of medication outside approved Federal Drug Administration indications properly.

Non-Coverage: Certain insurance plans do not provide coverage of Dupixent, while other coverage plans require strict approval procedures. The provider needs to find another treatment course for patients whose insurance companies declare Dupixent non-covered or provide assistance for insurance appeals.

Prior Authorization Delays: The approval process for Dupixent prior authorization demands a significant period of time. The process of obtaining approval delays the treatment administration resulting in detrimental impacts on care quality for patients while affecting payment cycles for providers.

## Documentation and Compliance

The correct documentation procedures play an essential role in Dupixent’s billing process. This includes:

Patient Records: Medical staff should maintain complete documentation of patient identification with Dupixent diagnosis along with treatment methods and prescription explanations.

Administration Details: Medical professionals should note both the time and dosage and administration date for each injection.

Patient Training: Every patient training session about Dupixent usage needs to be recorded in the medical records.

## Additional Codes for Dupixent-Related Services

Healthcare providers should keep J9228 as the main HCPCS code to bill Dupixent’s administration, but they will encounter supplementing codes that cover related services.

J3490: Providers can use J3490 as an unspecified code to bill other injectable medications when they lack their precise HCPCS code. Healthcare providers should use this code only in limited situations rather than opting for the J9228 code.

CPT Code 96401: When Mount Foris Medical Center administers Dupixent through office injections, they will probably use this CPT code to document the procedure.

## Conclusion

When healthcare providers conduct billing for Dupixent injection treatments for asthma and atopic dermatitis, and chronic rhino sinusitis, they need to use HCPCS code J9228. The successful processing of Dupixent billing within the healthcare system requires healthcare providers to understand the relationships between the J9228 code and dosage levels, ICD-10 disease classifications, and insurance payment regulations. Reliable coding practice allows patients to obtain required treatments without delay and enables appropriate payment to providers for their services.

Healthcare providers need to check the most recent information from the American Medical Association (AMA), CMS, and insurance carriers when preparing to code and bill treatments with Dupixent.

## FAQs:

### What is the HCPC code for Dupixent?

Dupilumab (Dupixent) has two approved Healthcare Common Procedure Coding System codes, namely C9399 and J3590. The two HCPCS codes are available for unclassified biologics.

### What is HCPCS code 97032?

The procedure of manual electrical stimulation therapy known as 97032, “Application of a modality to one or more areas; electrical stimulation (manual),” signifies direct healthcare professional involvement in patient treatment via sustained physical interaction throughout sessions under a code classification of “attended electrical stimulation.

### What is HCPCS code J1815?

HCPCS code J1815 specifies “Injection, insulin, per 5 units.” Therefore, it constitutes a billing code for insulin injections whose units reflect doses of 5 units of insulin.

### What is the HCPCS code for T2046?

According to CMS T2046 represents a Hospice long term care service which includes room and board at a per diem rate.

### Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Comment *

Name *

Email *

Website

Save my name, email, and website in this browser for the next time I comment.

Sidebar Scroll To Top